A CONVENIENT AND PRACTICAL CIMETIDINE PROTOCOL FOR ESTIMATION OF GLOMERULAR FILTRATION RATE (GFR). † 1659

A practical approach to glomerular filtration rate measurements: creatinine clearance estimation using cimetidine.

Determination of creatinine clearance (Ccr) is not a reliable indicator of glomerular filtration rate (GFR), owing to tubular secretion of creatinine. It has been reported that Ccr measurements can approximate true GFR after cimetidine (Ci) administration. In this study, GFR was estimated by Cockcroft and Gault's equation (C(C-G)) based on measurement of plasma creatinine, and Ccr was determine...

FIT to measure glomerular filtration rate ( GFR )

SERUM CYSTATIN C AS A NEW MARKER OF GLOMERULAR FILTRATION RATE (GFR)

Cystatin C is a 13 KD basic protein that is a member of the cystatin superfamily of cysteine protease inhibitors. The cystatin C gene seems to be a house keeping gene, which is compatible with a stable production rate of cystatin C by most cells. This protein is freely filtered through the glomerulus and almost completely reabsorbed and catabolized by proximal tubular cells. Because of the...

Estimation of Glomerular Filteration Rate (GFR)

I. Clearance Methods:The concept of renal clearance was introduced as a way of expressing the relation between the excretion per unit time and the concentration in the plasma which is obviously an index of kidneys ability to clear the blood of any substance (1). Measurements of GFR are traditionally based on the renal clearance of a marker in plasma, expressed as the volume of plasma completely...

Improved estimation of glomerular filtration rate (GFR) by comparison of eGFRcystatin C and eGFRcreatinine

OBJECTIVE GFR-prediction equations based upon cystatin C and creatinine have better diagnostic performance in estimating GFR than equations based upon only one of the two markers. The present work concerns in what way a comparison between separate estimations of GFR based upon cystatin C (eGFR(cystatin C)) or creatinine (eGFR(creatinine)) can be used to evaluate the diagnostic performance of a ...